Article
Genetic variation in caveolin-1 affects survival after lung transplantation.
Transplantation - 15 Aug 2014
Vandermeulen Elly, Ruttens David, Verleden Stijn E, Vos Robin, Van Raemdonck Dirk E, Kastelijn Elisabeth A, Wauters Els, Lambrechts Diether, Nawrot Tim S, Cox Bianca, Verleden Geert M, Vanaudenaerde Bart M
Abstract excerpt
BACKGROUND: Caveolin-1 (CAV-1), a structural protein of the cell membrane, is involved in tissue homeostasis, inflammation, oxidative stress, microbial clearance, and fibrosis. METHODS: We investigated a genetic predisposition of the CAV-1 gene on survival, acute and chronic rejection, lymphocytic bronchiolitis (LB), and respiratory infection after lung transplantation (LTx). RESULTS: In 503 of 568 patients, the...
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