Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon.

doi:10.1038/s41419-019-2057-4

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Article

Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon.

Cell death & disease - 28 Oct 2019

Burocziova Monika, Burdova Kamila, Martinikova Andra S, Kasparek Petr, Kleiblova Petra, Danielsen Stine A, Borecka Marianna, Jenikova Gabriela, Janečková Lucie, Pavel Jozef, Zemankova Petra, Schneiderova Michaela, Schwarzova Lucie, Ticha Ivana, Sun Xiao-Feng, Jiraskova Katerina, Liska Vaclav, Vodickova Ludmila, Vodicka Pavel, Sedlacek Radislav, Kleibl Zdenek, Lothe Ragnhild A, Korinek Vladimír, Macurek Libor

Abstract excerpt

Protein phosphatase magnesium-dependent 1 delta (PPM1D) terminates cell response to genotoxic stress by negatively regulating the tumor suppressor p53 and other targets at chromatin. Mutations in the exon 6 of the PPM1D result in production of a highly stable, C-terminally truncated PPM1D. These gain-of-function PPM1D mutations are present in various human cancers but their role in tumorigenesis remains...

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Identifiers

PMID: 31659152
DOI: 10.1038/s41419-019-2057-4
PMCID: PMC6817818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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