Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PPM1D in Solid and Hematologic Malignancies: Friend and Foe?

Molecular cancer research : MCR - 2 Sept 2022

Zhang Linda, Hsu Joanne I, Goodell Margaret A

Abstract excerpt

In the face of constant genomic insults, the DNA damage response (DDR) is initiated to preserve genome integrity; its disruption is a classic hallmark of cancer. Protein phosphatase Mg2+/Mn2+-dependent 1D (PPM1D) is a central negative regulator of the DDR that is mutated or amplified in many solid cancers. PPM1D overexpression is associated with increased proliferative and metastatic behavior in multiple solid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Acute Myeloid Leukemia Research
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Checkpoints

Share to DNA Repair

Share to Hematologic Neoplasms

Share to Hematopoietic Stem Cells

Share to Protein Phosphatase 2C

Source

Open in PubMed Open full text

Identifiers

PMID: 35657598
DOI: 10.1158/1541-7786.MCR-21-1018
PMCID: PMC9437564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPM1D in Solid and Hematologic Malignancies: Friend and Foe?PMID 35657598Read ↗

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic ChemotherapySemantic proximity Read ↗

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.Semantic proximity Read ↗

Protein phosphatase, Mg2+/Mn2+-dependent 1D (PPM1D) mutations in haematological cancer.Semantic proximity Read ↗

Clonal Evolution of PPM1D Mutations in the Spectrum of Myeloid DisordersSemantic proximity Read ↗

Ppm1d truncating mutations promote the development of genotoxic stress-induced AML.Semantic proximity Read ↗

Rising Prevalence of Low-Frequency PPM1D Gene Mutations after Second HDCT in Multiple MyelomaSemantic proximity Read ↗

The role of PPM1D in cancer and advances in studies of its inhibitorsSemantic proximity Read ↗

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.Semantic proximity Read ↗

Spectrum, prevalence, and clinical correlates of PPM1D mutations in patients with clonal hematopoiesis and clonal cytopenias.Semantic proximity Read ↗

SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells.Semantic proximity Read ↗

Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine gliomaSemantic proximity Read ↗

Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.