PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.

doi:10.1182/blood.2023020331

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Article

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.

Blood - 14 Dec 2023

Miller Peter G, Sperling Adam S, Mayerhofer Christina, McConkey Marie E, Ellegast Jana M, Da Silva Carmen, Cohen Drew N, Wang Chuqi, Sharda Azeem, Yan Ni, Saha Subha, Schluter Cameron, Schechter Ilexa, Słabicki Mikołaj, Sandoval Brittany, Kahn Josephine, Boettcher Steffen, Gibson Christopher J, Scadden David T, Stegmaier Kimberly, Bhatt Shruti, Lindsley R Coleman, Ebert Benjamin L

Abstract excerpt

PPM1D encodes a phosphatase that is recurrently activated across cancer, most notably in therapy-related myeloid neoplasms. However, the function of PPM1D in hematopoiesis and its contribution to tumor cell growth remain incompletely understood. Using conditional mouse models, we uncover a central role for Ppm1d in hematopoiesis and validate its potential as a therapeutic target. We find that Ppm1d regulates the...

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PMID: 37595362
DOI: 10.1182/blood.2023020331
PMCID: PMC10733824

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