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Article

Infertile females with biallelic mutations in APC/C genes are characterized by oocyte or early embryo defects.

Journal of assisted reproduction and genetics - 1 May 2025

Cui Ying, Zhao Shuai, Zhang Changlong, Su Wei, Chen Xiaolei, Wang Yang, Yang Bohan, Wu Keliang, Chen Zi-Jiang, Zhang Honghui, Zhao Han

Abstract excerpt

PURPOSE: The objective of this study was to elucidate the role of anaphase promoting complex/cyclosome (APC/C)-related genes in cases of female infertility characterized by disturbances in oocyte maturation, failure of fertilization, and cessation of early embryonic growth among three distinct Chinese familial lineages. METHODS: We conducted whole-exome sequencing of patients with female infertility from 639...

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Identifiers

PMID: 40238067
DOI: 10.1007/s10815-025-03465-x
PMCID: PMC12167399

Genes

APC
CDC23

Variants

Provenance

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