Article
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK.
Oncogene - 4 Apr 2013
Baker A-M, Bird D, Lang G, Cox T R, Erler J T
Abstract excerpt
The extracellular, matrix-modifying enzyme lysyl oxidase (LOX) has recently been linked to colorectal cancer (CRC) progression, in particular to the stages of invasion and metastasis. In this report, we use cell lines expressing a catalytically inactive mutant form of LOX to show that catalytic activity is required for LOX-mediated effects on proliferation and invasion in both in vitro and in vivo models of CRC....
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