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Article

KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint.

Current biology : CB - 7 Jun 2011

Rosenberg Jessica S, Cross Frederick R, Funabiki Hironori

Abstract excerpt

The spindle assembly checkpoint (SAC) delays anaphase onset until kinetochores accomplish bioriented microtubule attachments [1]. Although several centromeric and kinetochore kinases, including Aurora B, regulate kinetochore-microtubule attachment and/or SAC activation [2-4], the molecular mechan...

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Topics

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Share to Anaphase
Share to Conserved Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubule-Associated Proteins

Share to Mitosis

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Share to Protein Phosphatase 1

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Source

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Identifiers

PMID: 21640906
DOI: 10.1016/j.cub.2011.04.011
PMCID: PMC3109435

Genes

KNL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21640906-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint.PMID 21640906Read ↗

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.Semantic proximity Read ↗

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.Semantic proximity Read ↗

CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.Semantic proximity Read ↗

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.Semantic proximity Read ↗

Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.Semantic proximity Read ↗

Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase.Semantic proximity Read ↗

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.Semantic proximity Read ↗

The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15.Semantic proximity Read ↗

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.Semantic proximity Read ↗

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.Semantic proximity Read ↗

Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p.Semantic proximity Read ↗

Captivating capture: how microtubules attach to kinetochores.Semantic proximity Read ↗

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