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Multi-omic analysis of chronic myelomonocytic leukemia monocytes reveals metabolic and immune dysregulation leading to altered macrophage polarization

15 Jan 2025

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is a clonal myelodysplastic/myeloproliferative neoplasm characterized by persistent peripheral blood (PB) monocytosis with few effective treatment options [ 1 ]. CMML is genetically homogeneous, with the most commonly mutated gene class encoding epigenetic regulators, suggesting epigenetic dysregulation as a core hallmark of CMML biology [ 2 ]. However, few CMML-specific...

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PMID: 39815051
DOI: 10.1038/s41375-024-02511-4

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