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Article

Chronic myelomonocytic leukemia without increased classical monocyte subsets exhibits a distinct genetic profile, including frequent CBL mutations.

American journal of clinical pathology - 5 May 2026

Yan Mingfei, Younes Ismail Elbaz, Song Jinming, Zhang Ling

Abstract excerpt

OBJECTIVES: To characterize the genetic profiles of chronic myelomonocytic leukemia (CMML) cases that do not exhibit increased classical monocyte (CM) subsets in -peripheral blood. METHODS: A total of 174 patients with CMML who were treatment‑naive for hypomethylating agents and had undergone next‑generation sequencing (NGS) testing were analyzed. Among these, 152 patients (87.4%) demonstrated increased CM...

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Source

Identifiers

PMID: 42154859
DOI: 10.1093/ajcp/aqag045

Genes

CBL
IDH2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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