Article
Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma.
PloS one - 1 Jan 2016
Budzinska Magdalena A, Tu Thomas, d'Avigdor William M H, McCaughan Geoffrey W, Luciani Fabio, Shackel Nicholas A
Abstract excerpt
In hepatocellular carcinoma (HCC), somatic genome-wide DNA mutations are numerous, universal and heterogeneous. Some of these somatic mutations are drivers of the malignant process but the vast majority are passenger mutations. These passenger mutations can be deleterious to individual protein function but are tolerated by the cell or are offset by a survival advantage conferred by driver mutations. It is unknown...
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