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Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver

21 Apr 2023

Abstract excerpt

BACKGROUND & AIMS: While normal human liver is thought to be generally quiescent, clonal hepatocyte expansions have been observed, though neither their cellular source nor their expansion dynamics have been determined. Knowing the hepatocyte cell of origin, and their subsequent dynamics and trajectory within the human liver will provide an important basis to understand disease-associated dysregulation. METHODS:...

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PMID: 37088309
DOI: 10.1016/j.jhep.2023.03.044

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