Article
Drosophila Doublefault protein coordinates multiple events during male meiosis by controlling mRNA translation.
Development (Cambridge, England) - 18 Nov 2019
Sechi Stefano, Frappaolo Anna, Karimpour-Ghahnavieh Angela, Gottardo Marco, Burla Romina, Di Francesco Laura, Szafer-Glusman Edith, Schininà Eugenia, Fuller Margaret T, Saggio Isabella, Riparbelli Maria Giovanna, Callaini Giuliano, Giansanti Maria Grazia
Abstract excerpt
During the extended prophase of Drosophila gametogenesis, spermatocytes undergo robust gene transcription and store many transcripts in the cytoplasm in a repressed state, until translational activation of select mRNAs in later steps of spermatogenesis. Here, we characterize the Drosophila Doublefault (Dbf) protein as a C2H2 zinc-finger protein, primarily expressed in testes, that is required for normal meiotic...
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