Article
Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.
Reproduction (Cambridge, England) - 1 Jul 2013
Kleene Kenneth C
Abstract excerpt
mRNA-specific regulation of translational activity plays major roles in directing the development of meiotic and haploid spermatogenic cells in mammals. Although many RNA-binding proteins (RBPs) have been implicated in normal translational control and sperm development, little is known about the keystone of the mechanisms: the interactions of RBPs and microRNAs with cis-elements in mRNA targets. The problems in...
Topics
- 3' Untranslated Regions
- 5' Untranslated Regions
- Animals
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Gene Knockout Techniques
- Genes, mos
- Haploidy
- Humans
- Male
- Meiosis
- MicroRNAs
- Mitochondrial Proteins
- Mutation
- Open Reading Frames
- Protamines
- RNA, Small Interfering
- RNA-Binding Proteins