Article
Male-specific region of the Y chromosome and cardiovascular risk: phylogenetic analysis and gene expression studies.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2013
Bloomer Lisa D S, Nelson Christopher P, Eales James, Denniff Matthew, Christofidou Paraskevi, Debiec Radoslaw, Moore Jasbir, Zukowska-Szczechowska Ewa, Goodall Alison H, Thompson John, Samani Nilesh J, Charchar Fadi J, Tomaszewski Maciej
Abstract excerpt
OBJECTIVE: Haplogroup I of male-specific region of the human Y chromosome is associated with 50% increased risk of coronary artery disease. It is not clear to what extent conventional cardiovascular risk factors and genes of the male-specific region may explain this association. APPROACH AND RESULTS: A total of 1988 biologically unrelated men from 4 white European populations were genotyped using 11 Y chromosome...
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