Article
Three functional variants were identified to affect RPS24 expression and significantly associated with risk of colorectal cancer.
Archives of toxicology - 1 Jan 2020
Zou Danyi, Zhang Hongli, Ke Juntao, Li Jiaoyuan, Zhu Ying, Gong Yajie, Yang Yang, Tian Jianbo, Zhang Yi, Peng Xiating, Cai Kailin, Zhong Rong, Chang Jiang, Miao Xiaoping
Abstract excerpt
GWAS-identified 10q22.3 loci with lead SNP rs704017 are significantly associated with CRC risk in both Asian and European populations. However, the functional mechanism of this region is unclear. In this study, we performed a fine-mapping analysis to identify the causal SNPs. To identify potential functional SNPs in linkage disequilibrium with the lead SNP, we searched for the potential target genes using a Hi-C...
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