Integrated systematic functional screen and fine-mapping decipher the role and genetic regulation of RPS19 in colorectal cancer development.

doi:10.1007/s00204-024-03822-2

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Integrated systematic functional screen and fine-mapping decipher the role and genetic regulation of RPS19 in colorectal cancer development.

Archives of toxicology - 1 Oct 2024

Chen Can, Wang Wenzhuo, Ning Caibo, Lu Zequn, Zhang Ming, Zhu Ying, Tian Jianbo, Li Haijie, Ge Yue, Yang Beifang, Miao Xiaoping

Abstract excerpt

Despite genome-wide association studies (GWAS) have identified more than 200 risk loci associated with colorectal cancer (CRC), the causal genes or risk variants within these loci and their biological functions remain not fully revealed. Recently, the genomic locus 19q13.2, with the lead SNP rs1800469 was identified as a crucial CRC risk locus in Asian populations. However, the functional mechanism of this region...

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PMID: 39012505
DOI: 10.1007/s00204-024-03822-2

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