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Article

Identification of potential functional variants and genes at 18q21.1 associated with the carcinogenesis of colorectal cancer.

PLoS genetics - 1 Feb 2022

Cheng Xiaoqing, Zhang Fenglan, Gong Jingwen, Li Yige, Zhou Dan, Wang Jing, Vong Eu Gene, Yuan Ying, Lai Maode, Zhang Dandan

Abstract excerpt

Genome-wide association studies (GWAS) have identified more than 160 susceptibility loci for colorectal cancer (CRC). The effects of these variants, particularly their mechanisms, however, remain unclear. In this study, a comprehensive functional annotation of CRC-related GWAS signals was firstly conducted to identify the potential causal variants. We found that the SNP rs7229639 in intron 3 of SMAD7 at 18q21.1...

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Carcinogenesis
Colorectal Neoplasms
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 35108261
DOI: 10.1371/journal.pgen.1010050
PMCID: PMC8870576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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