Article
Integrative functional screen of genomic loci uncovers CCND2 and its genetic regulatory mechanism in colorectal cancer development.
Carcinogenesis - 20 Jan 2025
Li Bin, Wu Mei, Geng Hui, Li Yan, Chen Zhirui, Lu Zequn, Chen Xu, Wang Qiuhong, Song Shuxin, Li Xiangpan, Zhu Xu, Wei Yongchang, Zhu Ying, Miao Xiaoping, Tian Jianbo, Liu Jiuyang, Huang Chaoqun, Yang Xiaojun
Abstract excerpt
Although genome-wide association studies have identified dozens of loci associated with colorectal cancer (CRC) susceptibility, the causal genes or risk variants within these loci and their biological functions often remain elusive. Recently, the genomic locus 12p13.32, with the tag single-nucleotide polymorphism rs10774214, was identified as a crucial CRC risk locus in Asian populations. However, the functional...
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