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Article

Exploring Structural Perturbations Caused by Cancer-Related Mutations in Pyruvate Kinase M2: A Comparison with the Wild-Type Enzyme.

The journal of physical chemistry. B - 23 Apr 2026

Mitra Anandita, Paul Sandip

Abstract excerpt

One of the key glycolytic enzymes, pyruvate kinase (PKM2), is frequently found in mutated forms in cancer cells. While many have investigated the impact of the mutations on tumor size and progressions, their structural effects on the architecture of PKM2 have not been thoroughly studied. We examined 11 mutants using MD simulations and assessed their effects on structural dynamics, domain flexibility, and...

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Identifiers

PMID: 41872996
DOI: 10.1021/acs.jpcb.5c08286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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