Article
Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes.
Human molecular genetics - 15 Jul 2011
Carvajal-Carmona Luis G, Cazier Jean-Baptiste, Jones Angela M, Howarth Kimberley, Broderick Peter, Pittman Alan, Dobbins Sara, Tenesa Albert, Farrington Susan, Prendergast James, Theodoratou Evi, Barnetson Rebecca, Conti David, Newcomb Polly, Hopper John L, Jenkins Mark A, Gallinger Steven, Duggan David J, Campbell Harry, Kerr David, Casey Graham, Houlston Richard, Dunlop Malcolm, Tomlinson Ian
Abstract excerpt
We have previously identified several colorectal cancer (CRC)-associated polymorphisms using genome-wide association (GWA) analysis. We sought to fine-map the location of the functional variants for three of these regions at 8q23.3 (EIF3H), 16q22.1 (CDH1/CDH3) and 19q13.11 (RHPN2). We genotyped two case-control sets at high density in the selected regions and used existing data from four other case-control sets,...
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