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Article

Allele-specific enhancer interaction at the Peg3 imprinted domain.

PloS one - 1 Jan 2019

Kim Joomyeong, Frey Wesley D, Sharma Kaustubh, Ghimire Subash, Teruyama Ryoichi, Stubbs Lisa

Abstract excerpt

The parental allele specificity of mammalian imprinted genes has been evolutionarily well conserved, although its functional constraints and associated mechanisms are not fully understood. In the current study, we generated a mouse mutant with switched active alleles driving the switch from paternal-to-maternal expression for Peg3 and the maternal-to-paternal expression for Zim1. The expression levels of Peg3 and...

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Share to Chromosomes, Mammalian
Share to DNA-Binding Proteins
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation, Enzymologic

Share to Genomic Imprinting

Share to Kruppel-Like Transcription Factors

Share to Nerve Tissue Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 31639176
DOI: 10.1371/journal.pone.0224287
PMCID: PMC6804975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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