Article
Allele and dosage specificity of the Peg3 imprinted domain.
PloS one - 1 Jan 2018
Bretz Corey L, Frey Wesley D, Teruyama Ryoichi, Kim Joomyeong
Abstract excerpt
The biological impetus for gene dosage and allele specificity of mammalian imprinted genes is not fully understood. To address this, we generated and analyzed four sets of mice from a single breeding scheme with varying allelic expression and gene dosage of the Peg3 domain. The mutants with abrogation of the two paternally expressed genes, Peg3 and Usp29, showed a significant decrease in growth rates for both...
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