Article
Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment.
HGG advances - 11 Apr 2024
Rengifo Rojas Cecilia, Cercy Jil, Perillous Sophie, Gonthier-Guéret Céline, Montibus Bertille, Maupetit-Méhouas Stéphanie, Espinadel Astrid, Dupré Marylou, Hong Charles C, Hata Kenichiro, Nakabayashi Kazuhiko, Plagge Antonius, Bouschet Tristan, Arnaud Philippe, Vaillant Isabelle, Court Franck
Abstract excerpt
It is only partially understood how constitutive allelic methylation at imprinting control regions (ICRs) interacts with other regulation levels to drive timely parental allele-specific expression along large imprinted domains. The Peg13-Kcnk9 domain is an imprinted domain with important brain functions. To gain insights into its regulation during neural commitment, we performed an integrative analysis of its...
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