Article

A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screening

2018-08-01

Abstract excerpt

<h4>Background</h4> Clinical guidelines recommend microsatellite instability (MSI) and BRAF V600E testing of all colorectal cancers (CRCs) to screen for Lynch syndrome (LS), a hereditary predisposition to cancer. MSI is also associated with response to immunotherapy. However, uptake of MSI testing is poor and current assays are not suitable for high throughput diagnostics. We aimed to develop a cheap and scalab...

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Literature Corpus work: 35230ff5-3229-5da4-b574-1ad0629035cf
DOI: 10.1101/382754

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