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Article

Targeted next-generation sequencing-based detection of microsatellite instability in colorectal carcinomas.

PloS one - 1 Jan 2021

Lee Yunbeom, Lee Ji Ae, Park Hye Eun, Han Hyojun, Kim Yuhnam, Bae Jeong Mo, Kim Jung Ho, Cho Nam-Yun, Kim Hwang-Phill, Kim Tae-You, Kang Gyeong Hoon

Abstract excerpt

In the present study, we developed a computational method and panel markers to assess microsatellite instability (MSI) using a targeted next-generation sequencing (NGS) platform and compared the performance of our computational method, mSILICO, with that of mSINGS to detect MSI in CRCs. We evaluated 13 CRC cell lines, 84 fresh and 119 formalin-fixed CRC tissues (including 61 MSI-high CRCs and 155...

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Cell Line, Tumor
Colorectal Neoplasms
Genetic Predisposition to Disease
Genetic Testing
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Instability

Microsatellite Repeats

Sensitivity and Specificity

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Identifiers

PMID: 33524032
DOI: 10.1371/journal.pone.0246356
PMCID: PMC7850495

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