The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing.

doi:10.1038/s41598-024-72419-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing.

Scientific reports - 19 Sept 2024

Srihar Kanishta, Gusnanto Arief, Richman Susan D, West Nicholas P, Galvin Leanne, Bottomley Daniel, Hemmings Gemma, Glover Amy, Natarajan Subaashini, Miller Rebecca, Arif Sameira, Rossington Hannah, Dunwell Thomas L, Dailey Simon C, Fontarum Gracielle, George Agnes, Wu Winnie, Quirke Phil, Wood Henry M

Abstract excerpt

Microsatellite instability (MSI) occurs across a number of cancers and is associated with different clinical characteristics when compared to microsatellite stable (MSS) cancers. As MSI cancers have different characteristics, routine MSI testing is now recommended for a number of cancer types including colorectal cancer (CRC). Using gene panels for sequencing of known cancer mutations is routinely performed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to DNA Mutational Analysis

Share to Formaldehyde

Share to High-Throughput Nucleotide Sequencing

Share to Microsatellite Instability

Share to Paraffin Embedding

Share to Tissue Fixation

Source

Open in PubMed Open full text

Identifiers

PMID: 39300198
DOI: 10.1038/s41598-024-72419-7
PMCID: PMC11413368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing.PMID 39300198Read ↗

A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency.Semantic proximity Read ↗

Applicability of Next Generation Sequencing Technology in Microsatellite Instability TestingSemantic proximity Read ↗

Sequencing‐based microsatellite instability testing using as few as six markers for high‐throughput clinical diagnosticsSemantic proximity Read ↗

A novel NGS-based microsatellite instability (MSI) status classifier with 9 loci for colorectal cancer patients.Semantic proximity Read ↗

Targeted next-generation sequencing-based detection of microsatellite instability in colorectal carcinomas.Semantic proximity Read ↗

Accurate Pan-Cancer Molecular Diagnosis of Microsatellite Instability by Single-Molecule Molecular Inversion Probe Capture and High-Throughput SequencingSemantic proximity Read ↗

Microsatellite instability detection using a large next-generation sequencing cancer panel across diverse tumour typesSemantic proximity Read ↗

MSIseq: Software for Assessing Microsatellite Instability from Catalogs of Somatic MutationsSemantic proximity Read ↗

Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancersSemantic proximity Read ↗

A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screeningSemantic proximity Read ↗

Reliable Pan-Cancer Microsatellite Instability Assessment by Using Targeted Next-Generation Sequencing DataSemantic proximity Read ↗

Multi-center real-world comparison of the fully automated Idylla™ microsatellite instability assay with routine molecular methods and immunohistochemistry on formalin-fixed paraffin-embedded tissue of colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.