Article
Multi-center real-world comparison of the fully automated Idylla™ microsatellite instability assay with routine molecular methods and immunohistochemistry on formalin-fixed paraffin-embedded tissue of colorectal cancer.
Virchows Archiv : an international journal of pathology - 1 May 2021
Velasco Ana, Tokat Fatma, Bonde Jesper, Trim Nicola, Bauer Elisabeth, Meeney Adam, de Leng Wendy, Chong George, Dalstein Véronique, Kis Lorand L, Lorentzen Jon A, Tomić Snjezana, Thwaites Keeley, Putzová Martina, Birnbaum Astrid, Qazi Romena, Primmer Vanessa, Dockhorn-Dworniczak Barbara, Hernández-Losa Javier, Soares Fernando A, Gertler Asaf A, Kalman Michal, Wong Chris, Carraro Dirce M, Sousa Ana C, Reis Rui M, Fox Stephen B, Fassan Matteo, Brevet Marie, Merkelbach-Bruse Sabine, Colling Richard, Soilleux Elizabeth, Teo Ryan Yee Wei, D'Haene Nicky, Nolet Serge, Ristimäki Ari, Väisänen Timo, Chapusot Caroline, Soruri Afsaneh, Unger Tina, Wecgowiec Johanna, Biscuola Michele, Frattini Milo, Long Anna, Campregher Paulo V, Matias-Guiu Xavier
Abstract excerpt
Microsatellite instability (MSI) is present in 15-20% of primary colorectal cancers. MSI status is assessed to detect Lynch syndrome, guide adjuvant chemotherapy, determine prognosis, and use as a companion test for checkpoint blockade inhibitors. Traditionally, MSI status is determined by immunohistochemistry or molecular methods. The Idylla™ MSI Assay is a fully automated molecular method (including automated...
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