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Article

LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure.

Cell death & disease - 13 Oct 2021

Su Chi-Ting, Jao Tzu-Ming, Urban Zsolt, Huang Yue-Jhu, See Daniel H W, Tsai Yao-Chou, Lin Wei-Chou, Huang Jenq-Wen

Abstract excerpt

Transforming growth factor beta (TGFβ) signalling regulates extracellular matrix accumulation known to be essential for the pathogenesis of renal fibrosis; latent transforming growth factor beta binding protein 4 (LTBP4) is an important regulator of TGFβ activity. To date, the regulation of LTBP4 in renal fibrosis remains unknown. Herein, we report that LTBP4 is upregulated in patients with chronic kidney disease...

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Source

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Identifiers

PMID: 34645813
DOI: 10.1038/s41419-021-04214-5
PMCID: PMC8514500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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