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Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms

31 May 2022

Abstract excerpt

Zinc-dependent histone deacetylases (HDACs) and sirtuins (SIRT) represent two different classes of enzymes which are responsible for deacylation of modified lysine side chains. The repertoire of acyl residues on lysine side chains identified in vivo is rapidly growing, and very recently lysine lactoylation was described to be involved in metabolic reprogramming. Additionally, lysine pyruvoylation represents a...

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PMID: 35639992
DOI: 10.1021/acschembio.1c00863

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