Article
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
Nature communications - 9 Feb 2021
Davydova Erna, Shimazu Tadahiro, Schuhmacher Maren Kirstin, Jakobsson Magnus E, Willemen Hanneke L D M, Liu Tongri, Moen Anders, Ho Angela Y Y, Małecki Jędrzej, Schroer Lisa, Pinto Rita, Suzuki Takehiro, Grønsberg Ida A, Sohtome Yoshihiro, Akakabe Mai, Weirich Sara, Kikuchi Masaki, Olsen Jesper V, Dohmae Naoshi, Umehara Takashi, Sodeoka Mikiko, Siino Valentina, McDonough Michael A, Eijkelkamp Niels, Schofield Christopher J, Jeltsch Albert, Shinkai Yoichi, Falnes Pål Ø
Abstract excerpt
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a broad-specificity methyltransferase that mediates the formation of the majority of 1MH present in mouse and human...
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