HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

Abstract excerpt

Background: HIV-1 proviruses can persist during ART in clonally-expanded populations of CD4+ T cells. To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common. One such clone, denoted AMBI-1 (1), was also a source of persistent viremia on ART, begging the question of how the AMBI-1 clone can survive despite infection with a...

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