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Article

Lifespan of effector memory CD4+ T cells determined by replication-incompetent integrated HIV-1 provirus

3 Feb 2014

Abstract excerpt

OBJECTIVE: Determining the precise lifespan of human T-cell is challenging due to the inability of standard techniques to distinguish between dividing and dying cells. Here, we measured the lifespan of a pool of T cells that were derived from a single cell 'naturally' labelled with a single integrated clone of a replication-incompetent HIV-1 provirus. DESIGN/METHODS: Utilizing a combination of techniques, we were...

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PMID: 24492253
DOI: 10.1097/qad.0000000000000223

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