Article
HIV-1 replication is controlled at the level of T cell activation and proviral integration.
The EMBO journal - 1 May 1990
Stevenson M, Stanwick T L, Dempsey M P, Lamonica C A
Abstract excerpt
During progression of the Acquired Immune Deficiency Syndrome (AIDS), the human immunodeficiency virus type 1 (HIV-1) is harbored in CD4+ T cells, which act as the primary reservoir for the virus. In vitro, HIV-1 requires activated T cells for a productive infection; however, in vivo, the number of circulating T cells in the activated state that are potential targets for HIV-1 infection is low. We have...
Topics
- Acquired Immunodeficiency Syndrome
- DNA Nucleotidyltransferases
- DNA, Viral
- Gene Products, gag
- Gene Products, tat
- HIV-1
- Integrases
- Lymphocyte Activation
- Lysogeny
- Models, Genetic
- Mutation