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HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus

4 Oct 2020

Abstract excerpt

BACKGROUNDHIV-1 viremia that is not suppressed by combination antiretroviral therapy (ART) is generally attributed to incomplete medication adherence and/or drug resistance. We evaluated individuals referred by clinicians for nonsuppressible viremia (plasma HIV-1 RNA above 40 copies/mL) despite reported adherence to ART and the absence of drug resistance to the current ART regimen.METHODSSamples were collected...

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PMID: 33016926
DOI: 10.1172/jci138099

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