Article
Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA.
Kidney international - 1 Oct 1996
Yoder B K, Richards W G, Sommardahl C, Sweeney W E, Michaud E J, Wilkinson J E, Avner E D, Woychik R P
Abstract excerpt
Autosomal recessive polycystic kidney disease (ARPKD) is characterized by the formation of large collecting tubule and ductular cysts that often result in renal insufficiency within the first decade of life. Understanding the process leading to cyst formation will require the identification and c...
Topics
- Animals
- Blotting, Southern
- Body Weight
- DNA, Complementary
- Disease Models, Animal
- ErbB Receptors
- Genetic Therapy
- Genotype
- Kidney
- Kidney Concentrating Ability
- Lectins
- Mice
- Mice, Mutant Strains
- Plant Lectins
- Polycystic Kidney, Autosomal Recessive