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Article

Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy

17 Oct 2019

Abstract excerpt

MYCN-amplified (MNA) neuroblastoma is an aggressive neural crest-derived pediatric cancer. However, MYCN is indispensable for development and transcriptionally regulates extensive network of genes. Integrating anti-MYCN ChIP-seq and gene expression profiles of neuroblastoma patients revealed the metabolic enzymes, MTHFD2 and PAICS, required for one-carbon metabolism and purine biosynthesis were concomitantly...

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PMID: 31624245
DOI: 10.1038/s41419-019-2033-z

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