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Article

More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?

28 Apr 2020

Abstract excerpt

The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known until recently. MTHFD2 is highly expressed in embryos and a wide range of tumors but has low or absent expression in most adult differentiated tissues. Elevated MTHFD2 expression is associated with poor prognosis in both hematological and solid...

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Identifiers

PMID: 32411609
DOI: 10.3389/fonc.2020.00658

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