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Negative Effects of Age at Menarche on Risk of Cardiometabolic Diseases in Adulthood: A Mendelian Randomization Study

15 Oct 2019

Abstract excerpt

CONTEXT: Observational studies have demonstrated that early menarche is associated with cardiometabolic diseases, but confounding factors make it difficult to infer causality. OBJECTIVE: We used Mendelian randomization (MR) to examine whether age at menarche (AAM) is causally associated with type 2 diabetes (T2D), coronary artery disease (CAD) and cardiometabolic traits. DESIGN AND METHODS: A 2-sample MR analysis...

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PMID: 31614369
DOI: 10.1210/clinem/dgz071

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