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Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

19 Sept 2019

Abstract excerpt

Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) resident transmembrane protein. In our previous experiments we demonstrated neuroprotective effects of pridopidine, an agonist of S1R, in cellular and animal models of Huntington’s (HD) and Alzheimer’s (AD) disease. Consistent with previous observations, deletion of endogenous S1R with CRISPR/Cas9 in cultured hippocampal neurons resulted in fewer...

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PMID: 31607852
DOI: 10.3389/fnins.2019.01012

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