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Article

Lack of sigma-1 receptor exacerbates ALS progression in mice.

Neuroscience - 14 Jun 2013

Mavlyutov T A, Epstein M L, Verbny Y I, Huerta M S, Zaitoun I, Ziskind-Conhaim L, Ruoho A E

Abstract excerpt

The function of the sigma-1 receptor (S1R) has been implicated in modulating the activity of various ion channels. In the CNS S1R is enriched in cholinergic postsynaptic densities in spinal cord motoneurons (MNs). Mutations in S1R have been found in familial cases of amyotrophic lateral sclerosis (ALS). In this study we show that a knockout of S1R in the SOD1*G93A mouse model of ALS significantly reduces...

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Identifiers

PMID: 23458708
DOI: 10.1016/j.neuroscience.2013.02.035
PMCID: PMC3665351

Genes

SOD1

Variants

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