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Article

Pridopidine activates neuroprotective pathways impaired in Huntington Disease

27 Jul 2016

Abstract excerpt

Pridopidine has demonstrated improvement in Huntington Disease (HD) motor symptoms as measured by secondary endpoints in clinical trials. Originally described as a dopamine stabilizer, this mechanism is insufficient to explain the clinical and preclinical effects of pridopidine. This study therefore explored pridopidine's potential mechanisms of action. The effect of pridopidine versus sham treatment on...

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PMID: 27466197
DOI: 10.1093/hmg/ddw238

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