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Article

Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis

11 Jan 2013

Abstract excerpt

Intracellular accumulations of mutant, misfolded proteins are major pathological hallmarks of amyotrophic lateral sclerosis (ALS) and related disorders. Recently, mutations in Sigma receptor 1 (SigR1) have been found to cause a form of ALS and frontotemporal lobar degeneration (FTLD). Our goal was to pinpoint alterations and modifications of SigR1 in ALS and to determine how these changes contribute to the...

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PMID: 23314020
DOI: 10.1093/hmg/ddt008

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Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosisPMID 23314020Read ↗

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