Genetic Variation in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) Gene and Alcohol Withdrawal Severity.

doi:10.1111/acer.12991

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Genetic Variation in the Vesicular Monoamine Transporter 1 (VMAT1/SLC18A1) Gene and Alcohol Withdrawal Severity.

Alcoholism, clinical and experimental research - 1 Mar 2016

Dutta Nisha, Helton Sarah G, Schwandt Melanie, Zhu Xi, Momenan Reza, Lohoff Falk W

Abstract excerpt

BACKGROUND: Alcohol withdrawal (AW) can be a serious consequence of alcohol dependence and consists of various neurochemical adaptations in the brain. One such neuroadaptation occurs in the monoamine neurotransmitter system. Recently, a functional variant in the presynaptic vesicular monoamine transporter gene (VMAT1/SLC18A1-Thr136Ile-rs1390938) was found to significantly increase transport of monoamines into...

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PMID: 26876819
DOI: 10.1111/acer.12991

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