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Article

Transcriptional regulatory model of fibrosis progression in the human lung

10 Oct 2019

Abstract excerpt

To develop a systems biology model of fibrosis progression within the human lung we performed RNA sequencing and microRNA analysis on 95 samples obtained from 10 idiopathic pulmonary fibrosis (IPF) and 6 control lungs. Extent of fibrosis in each sample was assessed by microCT-measured alveolar surface density (ASD) and confirmed by histology. Regulatory gene expression networks were identified using linear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31600171
DOI: 10.1172/jci.insight.131597

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