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Integrative analysis of lung molecular signatures reveals key drivers of idiopathic pulmonary fibrosis

7 Dec 2021

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a high clinical burden. The molecular signatures of IPF were analyzed to distinguish molecular subgroups and identify key driver genes and therapeutic targets. METHODS: Thirteen datasets of lung tissue transcriptomics including 585 IPF patients and 362 normal controls were obtained from the databases and subjected to filtration of...

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PMID: 34876074
DOI: 10.1186/s12890-021-01749-3

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