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Sirtuins and SIRT6 in Carcinogenesis and in Diet

7 Oct 2019

Abstract excerpt

Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk...

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PMID: 31591350
DOI: 10.3390/ijms20194945

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