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Article

SIRT1: roles in aging and cancer

30 Nov 2008

Abstract excerpt

Aging and cancer both occur as a result of accumulated cellular damage, and both are related to the regulation of specific genes in the damage response. Recent research has unveiled connections between the mechanisms of aging and cancer, but how to prevent the development of cancer and increase longevity remain unknown. SIRT1 (the mammalian Sir2), which has NAD(+)-dependent class III histone deacetylase activity,...

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PMID: 19017485
DOI: 10.5483/bmbrep.2008.41.11.751

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