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Article

Inflammation and heart failure: a two-sample Mendelian randomization study.

Journal of cardiovascular medicine (Hagerstown, Md.) - 1 Nov 2022

Remmelzwaal Sharon, van Oort Sabine, Handoko M Louis, van Empel Vanessa, Heymans Stephane R B, Beulens Joline W J

Abstract excerpt

BACKGROUND: It is hypothesized that inflammation leads to heart failure. Results from observational studies thus far have been inconsistent and it is unclear whether inflammation is causally associated with new-onset heart failure. Mendelian randomization analyses are less prone to biases common in observational studies such as reverse causation and unmeasured confounding. The aim of this study was to investigate...

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Identifiers

PMID: 36166332
DOI: 10.2459/JCM.0000000000001373

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