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Article

A Positive Causal Influence of IL-18 Levels on the Risk of T2DM: A Mendelian Randomization Study

5 Apr 2019

Abstract excerpt

A large number of clinical studies have shown that interleukin-18 (IL-18) plasma levels are positively correlated with the pathogenesis and development of type 2 diabetes mellitus (T2DM), but it remains unclear whether IL-18 causes T2DM, primarily due to the influence of reverse causality and residual confounding factors. Genome-wide association studies have led to the discovery of numerous common variants...

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PMID: 31024619
DOI: 10.3389/fgene.2019.00295

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