Article

Targeting IDO1 Suppresses RPE Ferroptosis and NLRP3 Inflammasome Activation and Ameliorates NaIO₃-Induced dry age-related macular degeneration

2026-07-08

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Dry age-related macular degeneration (AMD) is a common chronic degenerative ocular disease for which no effective disease-modifying therapeutic options to date. Indoleamine 2,3-dioxygenase 1 (IDO1) has been reported to reshape cellular redox and metabolic states through ferroptosis; however, its potential involvement in the pathogenesis of dry AMD remains la...

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Literature Corpus work: b4f34944-ae44-5770-bd74-29c60f08cebb
DOI: 10.21203/rs.3.rs-10183325/v1

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